Proteases, a vital enzyme family encoded by the human genome, play a crucial role in numerous physiological and pathological processes. By catalyzing the hydrolysis of peptide bonds, they contribute to the regulation of proteolysis mechanisms central to cell proliferation, embryonic development, tissue remodeling, protein activation, maturation, transport, and catabolism. Given their significant involvement in various signaling pathways, proteases represent promising drug targets for a wide range of diseases, including cardiovascular disorders, cancer, and viral infections.
At Creative Bioarray, we understand the challenges researchers face in drug discovery. Our Protease Screening Services are specifically designed to provide comprehensive profiling and screening of potential drug inhibitors targeting protease enzymes.
Why Focus on Proteases?
Proteases are pivotal in drug development. For instance, there are eight approved compounds for HIV treatment classified as protease inhibitors. Additionally, these inhibitors are being investigated for their applications in treating Hepatitis C, Type II diabetes, Alzheimer’s disease, and more. The focus on protease screening is critical for identifying new therapeutic interventions.
Our Protease Screening Services
Creative Bioarray offers an extensive range of services tailored to facilitate your drug discovery process. With over 50 proteases from diverse families—including cysteine, metalloproteinases, serine, threonine, and aspartic proteases—we provide a flexible and defined screening service.
Key Services Include:
- High Throughput Screening: Efficient evaluation of large compound libraries.
- IC50 Profiling: 10-dose curve fitting for accurate binding affinity assessments.
- Custom Assay Development: Tailored solutions based on specific research needs.
- Protease Substrate Determination: Utilizing peptide libraries to identify specific interactions.
Target Proteases
Our screening services encompass a variety of protease targets, including:
- Cysteine Proteases: Such as Caspases, Cathepsins, and Calpain.
- Metalloproteases: Including MMPs (Matrix Metalloproteinases) and ACE (Angiotensin-Converting Enzyme).
- Serine Proteases: Like Thrombin, Factor Xa, and Trypsin.
- Aspartate Proteases: Such as Cathepsin D and Renin.
Advantages of Our Services
- High Sensitivity and Reproducibility: Ensuring reliable and consistent data results.
- Minimal Sample Requirements: Only nanoliters of compounds needed.
- Rapid Data Delivery: Receive findings within days of compound submission.
- Expert Guidance: Access project support and answers in a timely manner.
At Creative Bioarray, we are dedicated to accelerating your drug discovery through our comprehensive Protease Screening Services. We pride ourselves on delivering high-quality data with a fast turnaround. If you have any specific requirements for protease screening and profiling, don’t hesitate to reach out.
